It offers excellent tools to evaluate your investments, including an asset allocation inspector, fee analyzer, and retirement planner. It enables you to track all of your income and expenses by category. Why Empower is my top pick, however, goes far beyond tracking your balance sheet. Once linked, it automatically pulls in all transactions and balances and tracks your net worth over time. You can also add accounts without online logins manually (e.g., artwork or vehicles). With Empower, you link all your financial accounts (it secures your data with AES-256 encryption). Previously called Personal Capital, it's still free and no other tool offers more features. Empower– Editor's ChoiceĮmpower is without question the best net worth tracker available today. Here are some tools that can make tracking your net worth easy and informative: 1. Of course, net worth doesn't always go up, which is one reason I have tracked our net worth for about 20 years. The growth has largely followed the increase in real estate prices and stocks. Household net worth has grown substantially over the last few years, as tracked by the Fed. Kubera does cost $150 a year, but they offer a 14-day trial for $1. While it doesn't offer portfolio analysis tools at present, it does give you visibility into individual holdings. It links with just about every financial institution out there, including crypto accounts. Kubera–For those that just want to track net worth, Kubera offers a very clean interface.Beyond tracking your net worth, Empower also offers a wealth of tools and charts to evaluate your finances. You can connect bank accounts, credit cards, investment accounts, retirement accounts, crypto, and even real estate via Zillow. Empower–This free tool, previously called Personal Capital, is my top pick for tracking your net worth.Here are the two I think are the best of the best. There are countless free and paid tools you can use to track your net worth. With that in mind, what follows is a list of what I think are the top net worth apps available today. These calculators then regularly update your net worth and keep track of changes over time. They can connect bank accounts, credit cards, investment and retirement accounts, and even the value of your home. They enable you to connect accounts to automatically pull in data. The best net worth calculators, however, do far more than simple math. For most of them, you enter the value of your assets and liabilities, and the calculator does the simple math to show you how much you're worth. There are plenty of free net worth trackers on the internet.
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Regorafenib or trifluridine-tipiracil is used after failure of 2 lines of therapy, 1, 2 with modest benefit in overall survival and progression-free survival (PFS). 7 In fact, the genetic landscape of cancer cell clones is continuously evolving for the selective pressure of different therapies. 6 After anti-EGFR treatment is stopped, RAS mutant clones decay with a half-life of approximately 4 months, whereas RAS WT clones increase. A subsequent treatment, such as chemotherapy plus antiangiogenic drugs, could cause the disappearance of RAS mutant clones and potentially restore sensitivity to anti-EGFR drugs. 3, 4 Whereas the majority of RAS WT cancer cells are killed by chemotherapy plus cetuximab or panitumumab, a genetic selection of RAS mutant cancer cells occurs with tumor progression. 1, 2 Despite initial efficacy, acquired resistance mechanisms, including KRAS or NRAS alterations, 3 - 5 are associated with treatment failure in all patients. Trial Registration Identifier: NCT05468892Īnti–epidermal growth factor receptor (EGFR) monoclonal antibodies plus cytotoxic drugs are the treatment cornerstone for RAS wild-type (WT) metastatic colorectal cancer (MCRC). The findings support the clinical utility of liquid biopsy–guided anti-EGFR rechallenge therapy for refractory RAS WT MCRC. Within this group of 15 patients, 2 (13.3%) had partial response, 11 (73.3%) had stable disease, and 2 (13.3%) had disease progression as best response.Ĭonclusions and Relevance In this RCT, third-line treatment with the anti-EGFR monoclonal antibody panitumumab plus the standard-of-care trifluridine-tipiracil resulted in improved PFS compared with treatment with trifluridine-tipiracil alone among patients with refractory RAS WT MCRC. A ctDNA liquid-biopsy extended mutation analysis by FoundationOne Liquid CDx (profiling 324 genes) was performed in a subgroup of patients with baseline plasma RAS/BRAF WT ctDNA in 15 of 23 patients (65.2%) whose tumors were WT for KRAS, NRAS, BRAFV600E, EGFR, ERBB2, MAP2K1, and PIK3CA, median PFS was 6.4 months (95% CI, 3.7-9.2 months). Pretreatment plasma RAS/BRAF WT ctDNA identified patients obtaining prolonged clinical benefit with panitumumab plus trifluridine-tipiracil compared with trifluridine-tipiracil, with PFS rates at 6 months of 38.5% vs 13.0% and at 12 months of 15.4% vs 0%. Median PFS was 4.0 months (95% CI, 2.8-5.3 months) in the panitumumab plus trifluridine-tipiracil arm vs 2.5 months (95% CI, 1.4-3.6 months) in the trifluridine-tipiracil only (hazard ratio, 0.48 95% CI, 0.28-0.82 P = .007). Results Of 62 included patients, 31 received panitumumab plus trifluridine-tipiracil (19 male median age, 65 years ) and 31 received trifluridine-tipiracil alone (17 male median age, 66 years ). Circulating tumor DNA (ctDNA) extended sequence variation analysis was performed in a subgroup of patients. Main Outcomes and Measures The primary end point was progression-free survival (PFS). Interventions Patients were randomized 1:1 to receive panitumumab plus trifluridine-tipiracil or trifluridine-tipiracil alone. Patients with refractory RAS WT MCRC who had a partial or complete response to first-line chemotherapy plus an anti-EGFR monoclonal antibody and an anti-EGFR drug–free interval of 4 or more months during second-line therapy were included. Objective To compare the anti-EGFR monoclonal antibody panitumumab plus standard-of-care trifluridine-tipiracil with trifluridine-tipiracil alone as third-line therapy for RAS WT MCRC.ĭesign, Setting, and Participants This phase 2 randomized clinical trial (RCT) was conducted in 7 Italian centers from June 2019 to April 2022. Rechallenge with epidermal growth factor receptor (EGFR) inhibitors for RAS wild-type (WT) MCRC may be valuable for these patients. Importance Current third-line therapies for patients with metastatic colorectal cancer (MCRC) have limited efficacy. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. They become adults before their pond disappears. The young of some Dragonfly species develop quickly from eggs laid when adults visit the ponds in spring, their rate of development “goosed” by the warming water temperatures. Many midge larvae live in low oxygen habitats their color comes from a hemoglobin-like pigment that helps them hang onto oxygen. The aptly-named Bloodworm is a fly larva, one of the midges. Two species of Wisconsin frog (Green and Bull frogs) do not lay eggs in EPs their tadpoles take two summers to mature and so need permanent water. Their Tadpoles mature fast, so they can hop away when the pond disappears (these are “land frogs” as adults). TadpolesĮPs are magnets for breeding amphibians, which must lay their soft eggs in water. Here are some of this spring’s crop, including a few “newborns.” Remember, the BugLady’s working definition of “bug” is rather catholic. Others may star in their own episodes someday soon. Many citizens of the EP-like damselflies, snails, marsh treaders, daphnia, water sowbugs, phantom midges, scuds, and soldier flies-are not pictured in this episode but have been featured in these pages previously and are archived. For information about EPs and an Ephemeral Pond Citizen Science monitoring project. Wood frogs, blue-spotted salamanders and fairy shrimp are considered obligate EP species in Wisconsin, and finding empty caddis fly cases or encysted fairy shrimp eggs in the leaf litter of a dry depression in fall also identifies it as an EP. Not every puddle that disappears seasonally is an Ephemeral Pond the presence of certain indicator species verifies its status. Do EP animals live there because they’ve developed adaptations that let them survive drought, or do they live there because the EP’s cycles give them something they need-a dry period? Yes. The annual drought makes EPs unsuitable for fish, which wreak havoc if they do find their way into an EP from nearby waterways in flood time. As the water evaporates, its inhabitants squeeze into increasingly smaller spaces water quality declines as waste products, including carbon dioxide, increase and food gets harder to find. The still, shallow water warms quickly and contains little oxygen. The wonder of EPs is that they are populated by animals that take the disappearing water in stride-animals that are prepared to dry up with the pond or to get out of Dodge (timing IS everything), and therein lie many tales.Īn astonishing array of animals use EPs as a place to drink, hunt, and breed, but an EP is a challenging place to call home. These are here-today-and-gone-tomorrow ponds, gather-ye-rosebuds-while-ye-may wetlands. Ephemeral ponds are (most years) just that-ephemeral. She loves the cycles of ephemeral ponds and the critters they contain (they’re also called vernal/spring ponds, but because some hold water in fall instead of spring, “ephemeral” is a more inclusive term). The BugLady has been hanging out at her local ephemeral pond again, looking at small things in the water.
Stranded Deep - Early Access v0.74.00 +13 TRAINERįile Archive - u1 - CN Text - Can return a false AV Positive! File = Clean! Stranded Deep - Early Access v0.76.00 +20 TRAINERįile Archive - u2 - CN Text - Can return a false AV Positive! File = Clean! Stranded Deep - Early Access v0.90.00 +26 TRAINERįile Archive - u4 - CN Text - Can return a false AV Positive! File = Clean!įile Archive - u3 - CN Text - Can return a false AV Positive! File = Clean! Stranded Deep - Early Access v0.90.11 +26 TRAINERįile Archive - u5 - CN Text - Can return a false AV Positive! File = Clean!
Morimoto Elite – The best of the best from Morimoto.A very effective way to increase the overall look of your headlights and make your vehicle stand out from the others around it. Clear Reflectors – Replace the factory amber side reflectors in your headlights with clear or smoked reflectors.Projector Brackets – Making retrofitting projectors into your headlights easier than ever! Available for some headlights allowing you to easily bolt-on brighter and better HID or LED projectors.A clear lens swap will allow you to experience the projector’s full performance potential to maximize width, colour, cutoff sharpness and intensity. And neither are the glass lenses on your OEM projectors. Clear Lenses – Let’s face it stock isn’t great.Find your favourite style for your headlights! Projector Shrouds – Shrouds add the factory-finished look of your headlights after a projector conversion by hiding any mods or hardware.These a fully built, ready to retrofit units with everything you need to upgrade to beautiful LED light output allowing you to clearly see the road ahead without blinding the drivers in front you. LED Projectors – LED projectors are the newest way to upgrade the overall performance of your headlights.Capture the powerful light of HID bulbs into a controlled beam pattern for seeing farther and wider down the road than ever before. We carry a wide range of sizes and types to suit any retrofitting needs. HID Projectors – When it comes down to pure headlight performance nothing beats proper HID projectors.This will take the guessing out what will fit and work in your vehicle best. Vehicle Specific Retrofit Kits – Retrofit kits built specifically for your vehicle model! Spec’d out with all the best components you will need to retrofit high performance projectors into your vehicle.Universal Retrofit Kits – Power is nothing without the ability to control it! Complete projector retrofit kits include all of the components to convert your headlights to a projector-based lighting system for unbeatable performance. You should carry out your own evaluation and verification exercise before choosing to rely upon any of the content in any way.ġ. We make no warranty, representation or guarantee that the content is error free or fit for your intended use. Your use of the content is entirely at your own risk. To the fullest extent permitted by applicable law, WO excludes all warranties or representations (express or implied) in respect of the content. Therefore any element of the content which involves a forecast or a prediction should not be relied upon as though it were a statement of fact. 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Sometimes, in any chapter at the resort, if the Character kicks a beachball, that are located throughout the beach, the player will lose all health and die. Resort beachball of death bug (PC Version) With help, you can go after lvl 44-49 Thug in their game to boost the XP faster, as for example a level 1 player with level 1 Knuckles hitting a level 46 Thug will grant them level 1–39, 40 if your kick critical does not become too high. The best boosting method of this Glitch, is having a friend (online player) to host a co-op game in which he is at the level cap. It is suggested not to use Bone Breaker as it will become a wasted 1-3 skill points. An example if being done correct, at level 40 each punch should show 380–400 XP on each hit (depending on level of Thug). With Sam B and the skill Motivation, when you come across a Thug that has toxic fumes, you have the ability to use this glitch to the max as for a maxed skill with 30% return on stamina, you can deal low damage to the broken limb and never get low on stamina from punching with the broken Brass knuckles because the toxic fume which does low damage will activate the skill plus Rebirth (or below). A good place to do this is where you first enter the Parking Lot. XP varies from player level and Thug level. You will gain XP for every hit when target the top of his shoulder blade correctly. Use the Left Hand of Glova to knock a Thug off its feet and follow up breaking an arm, but it would be recommendable to use your fists (or weak Brass Knuckles) to prevent quick death of the Thug. Creating the left hand of glova would require 5 Diamonds. This is the blueprint for the left hand of glova. The "easy" method is after getting 666 Dev. Also with fast traveling, you can only spawn at set checkpoints. Some time later it returns back to normal. It happens randomly, especially when you need to get away from danger but suddenly can't because the sprint key has stopped working. When fast traveling, sometimes you can't sprint for an undefined amount of time. Still, it is possible to use it while crouching but it may take some time to aim it successfully. Sometimes the radio that is supposed to be on the floor next to Bill is in fact inside the floor. Kicking the chairs or hitting them with a weapon, so he is able to move a step, will trigger the next dialogue (PC version). The chairs appear to block the NPC, preventing the quest from completing. That got the quest to finish up for me (360). **Don't forget to hit the cash register in the concession area both times for a big payout - almost $2000 each time for me**Īlternatively, you can just kick the chairs around in the security office until the guard starts moving again. This will "reset" the mission and it will see that you've done the computers, and instruct you to return to the security office, where the guy will tell you how to get to the parking structure. To get past the glitch, after resetting all of the computers (don't worry about the one without the keyboard), back track to the last mission (as if you are going to where the guard wants morphine) - you'll have to jump over the desks and break the door glass to the dark hallway outside of the server room (don't worry, there won't be any zombies). There is a PC that is blue screened, but has no keyboard, but it doesn't require resetting in order to complete the side mission. After resetting all of the terminals, there is no waypoint to return to the security office and if you do, the guard tells you to go back and finish. There's a confirmed glitch in the PC release of the "Born to be Wild" mission during the server room firewall reset portion.
A balance of $1,000 on the Venture Rewards card will cost you between $16 and $24 in monthly interest charges, depending on your credit score, which will almost certainly outweigh the value of any miles you earn.Īssuming you do pay off your balance each month, Venture Rewards can offer attractive rewards, especially in the first year. If you tend to carry a balance, a rewards credit card may not be a good idea for you. To offset the fee, you need to spend at least $396 per month, provided you redeem for travel at one cent per mile and pay off the balance in full every month. With an annual fee of $95, Capital One Venture Rewards offers a lower price compared to many top travel cards. Plus, while the flat rate may be convenient, it doesn’t allow for higher rewards in categories where some cardholders spend the most. If you’re a heavy traveler, Capital One Venture Rewards has its drawbacks, such as lacking free airport lounge access. Cardholders can also transfer miles to airline and hotel loyalty programs or use them through Capital One’s portal, if they choose. That’s a relatively unusual feature that could make the card far easier to use for many travelers. In addition to the card’s lucrative rewards, Capital One allows you to redeem Venture miles as a statement credit for recent travel purchases, rather than requiring you to book travel through its proprietary portal. Key perks: Two free lounge visits per year, Hertz Five Star status, $100 Global Entry/TSA Precheck fee credit every four years.Sign-up bonus: 75,000 miles after spending $4,000 in the first three months (worth $750 when redeemed for travel at one cent per mile).Bonus rewards: 5x on hotels and rental cars booked through Capital One. Rolling Storm Damage ReportsĪs storms strike, this interactive map is your guide to impacts and damage reports coming into National Weather Service stations nationwide. Track all current severe weather warnings, watches and advisories for Henderson, Kentucky and other areas in the United States on the interactive weather alerts page. Weather Alerts: Warnings, Watches and Advisories It will automatically update every 15 minutes. This smoke was also mixed with with aerosols from industrial activity, particularly over and near the Bay of Campeche and the Yucatan Peninsula.Īs severe weather or blizzards threaten, this database scrapes power outage information from more than 1,000 companies nationwide. Light smoke from widespread burning activity, was observed over much of southern Mexico, the adjacent Pacific Ocean waters, the Bay of Campeche, and northern Central America. SMOKE/AEROSOL: Gulf of Mexico, Yucatan Peninsula, southern Mexico, Northern Central America. east of the Rocky Mountains as far south as the northern Gulf of Mexico. Light smoke from the various Canadian fires, as well as agricultural burning, covered most of Canada, and much of the U.S. The mentioned fires in Quebec were also observed to still be producing plumes high-density smoke, now generally moving northward. This smoke then became combined with smoke mainly emitted from fires in Ontario and Quebec, with moderate to high-density smoke extending from the Great Lakes and Mid-Atlantic regions over the Atlantic Ocean southeast of New England and Nova Scotia. Moderate smoke from these fires also extended across all of the Canadian territories and over Hudson Bay, and additional areas of the central U.S. Descriptive text narrative for smoke/dust observed in satelite imagery through June 9, 2023, 8 p.m.Ĭanada, Central and Eastern United States and the northwestern Atlantic Ocean - Wildfires throughout Saskatchewan, Alberta, British Columbia, and the southern Northwest Territories continued to produce large amounts of high-density smoke extending from southeastern Yukon to northern Montana, North Dakota, and Minnesota and western Ontario. |
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